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Thread: difference between dopamine and opiate receptors

  1. #1

    Default difference between dopamine and opiate receptors

    Can anyone explain the difference between the two and their.various roles
    Self admitted Yohimburn ES addict
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    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

  2. #2
    Cyp
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    They are probably very similar. I know for a fact that once you get hooked to something such as a pain killers.... your receptors are raw and always searching for some kind of replacement.
    Last edited by Cyp; 12-26-2010 at 12:29 PM.

  3. #3

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    Yeah ocd sucks. You always replace one high for another.

  4. #4
    Chairman of the Board Ulter's Avatar
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    Well, obviously they are two different receptors for two different chemicals.
    The opiate receptor works by triggering the dopamine release thats bind to... you guessed it, the dopamine receptor.
    And you know what happens when that happens. Well maybe.
    The opiate receptor activation decreases GABA release, which normally inhibits dopamine release, so dopamine release is increased.

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    Hmm...im trying to follow ya ulter. I know there is a strong connection between the two and i just wwanna have a better understanding on how activation of dopamine or opiate receptors effects the other and vise versa.

    THeres a huge opiate epidemic here on LI, and i feel like certain dopamine agonist SHOULD help alleviate opiate WDs. Wanna help some struggling buddies out. Suboxone helps, but too many people end up hooked on that..which is just another opiate. Its like an alcoholic trying to kick his whiskey habit and using bud light instread...STILL ALCOHOL
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

  6. #6
    Chairman of the Board Ulter's Avatar
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    Yes, they use drugs like Prami (DA) to help addicts come off.

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  7. #7
    Cyp
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    Quote Originally Posted by ricorico View Post
    Suboxone helps, but too many people end up hooked on that..which is just another opiate. Its like an alcoholic trying to kick his whiskey habit and using bud light instread...STILL ALCOHOL
    The first time I used suboxone I had no issues coming off, no wd at all. However after the second and third time, I did experience some mild wd. It was nothing compared to the hell of coming off regular opiates. I believe that your brain very easily gets used to drugs, and its tricked the first or second time using drugs such as suboxone. Eventually it will get harder and harder to come off . Kinda of like once you get hooked on any kind of opiate your screwed...even a low dose forces your brain or its receptors to latch on much quicker then the average person would.

  8. #8
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    Quote Originally Posted by Cyp View Post
    The first time I used suboxone I had no issues coming off, no wd at all. However after the second and third time, I did experience some mild wd. It was nothing compared to the hell of coming off regular opiates. I believe that your brain very easily gets used to drugs, and its tricked the first or second time using drugs such as suboxone. Eventually it will get harder and harder to come off . Kinda of like once you get hooked on any kind of opiate your screwed...even a low dose forces your brain or its receptors to latch on much quicker then the average person would.
    Your experience was much different than mine....I thought suboxone wds were worse. Less physical, but worse pyscologically...I actually wanted to die
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

  9. #9
    Cyp
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    This past time, I did have same psychological issues. I had the worst time sleeping, it was such a nuisance. I was thoroughly depressed as well, which I'm sure was due to the dopamine suppression. Again these symptoms got progressively worse the more I went on opiates, and had to use suboxone to come off.

    I can tell you that one time I tried to do it on my own with out the supervision of a doctor. I had a handful of the tabs, and figured I could come off much faster. I was horribly wrong, and went through the worse WD I had ever gone through. The thought of ending it all was scary close, and at the time seemed like the only way out. I would not wish that upon anyone, it truly was hell. It really scarred me about coming of again after my back surgery. I almost made the choice to just stay on. It's such a horrible feeling knowing that for you to function normally your dependent on a drug, while the rest of the world passes by. I did not want to be that person, so I got back on Suboxone, and slowly tapered off. When I got down to 1/4 I stopped a little too soon, and experience mild physical wd, which were very tolerable. As mentioned before, I did experience depression and insomnia, which was obviously my system being out of whack, and took time my dopamine, and serotonin to establish a normal balance. Having the support of friends, and family is truly the key. I am in debt to a couple of close friends, and hope that I can return the favor one day.

    This opiate epidemic is horrible and sadly those who are in need of help are looked at as a out cast, or better yet someone who is weak. Our doctors are the ones that are fucking us here. Its so easy for them to solve every problem with a pill. They are more of a legal drug dealer then anything. How easy is it to go in to the doctors office, and tell them what you want and get it. Then when your hooked and you approach them for help, your tossed out with the rest of the medical waste. It happen to me, and really leaves you feeling helpless.

    Unfortunately I don't see anything changing anytime soon. A nice start would be to change how society looks at this problem. So those in need don't feel so ashamed, and alone.

  10. #10
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    Quote Originally Posted by Cyp View Post
    This past time, I did have same psychological issues. I had the worst time sleeping, it was such a nuisance. I was thoroughly depressed as well, which I'm sure was due to the dopamine suppression. Again these symptoms got progressively worse the more I went on opiates, and had to use suboxone to come off.

    I can tell you that one time I tried to do it on my own with out the supervision of a doctor. I had a handful of the tabs, and figured I could come off much faster. I was horribly wrong, and went through the worse WD I had ever gone through. The thought of ending it all was scary close, and at the time seemed like the only way out. I would not wish that upon anyone, it truly was hell. It really scarred me about coming of again after my back surgery. I almost made the choice to just stay on. It's such a horrible feeling knowing that for you to function normally your dependent on a drug, while the rest of the world passes by. I did not want to be that person, so I got back on Suboxone, and slowly tapered off. When I got down to 1/4 I stopped a little too soon, and experience mild physical wd, which were very tolerable. As mentioned before, I did experience depression and insomnia, which was obviously my system being out of whack, and took time my dopamine, and serotonin to establish a normal balance. Having the support of friends, and family is truly the key. I am in debt to a couple of close friends, and hope that I can return the favor one day.

    This opiate epidemic is horrible and sadly those who are in need of help are looked at as a out cast, or better yet someone who is weak. Our doctors are the ones that are fucking us here. Its so easy for them to solve every problem with a pill. They are more of a legal drug dealer then anything. How easy is it to go in to the doctors office, and tell them what you want and get it. Then when your hooked and you approach them for help, your tossed out with the rest of the medical waste. It happen to me, and really leaves you feeling helpless.

    Unfortunately I don't see anything changing anytime soon. A nice start would be to change how society looks at this problem. So those in need don't feel so ashamed, and alone.
    yea, some doc offices are just pill mills who wil give you anything you want. However, i definatly think that pain pills have their place in medicin as ive needed them many times before.

    With suboxone tapering, ithink its crucial to get down to just a crumb a day and then at the very end start doing EOD dosing. COming off of subs at 2mg, would make me wanna slit my wrists. I remembver how AWFUL i felt when i tried that. It was the worst. I had to get back on and taper off again.

    I have a friend who was popping 15x 30mg roxys a day. He just quit and needed to take 24mg sub the first few days. I cant imagine needing that much....and fuck, imagin taking that much oxycodone a day!!! jeeez

    I think adding prami after a suboxone run would offset that depressing feeling. THis why i was asking my quetsion in the first place. It seems to make sense that taking a D1, D2, or D3 agonist would alleviate some opiate WDs
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

  11. #11

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    well i really didnt plan on going into this but the reason for my disappearence was painkillers. started small no problems and it got OUT OF CONTROL. rico those 15x30mg roxys woulda been gone within an hour of waking up. a normal day was about 24x30mg roxy 4x10mg percs 2x30mg morphine 4x1600mcg OTFC (Fentanyl) lolipops the serious shit. to me it just kinda krept up on me. ive had six surgeries and the shit just stops working. then you realize your a retard but scared as hell to come off. now what i did is cut the lolipops/morphine/percs out so i was just (lol) t'king all the roxies. now imo opinion everyone is different. but this tapering bullshit just wasnt going to work for me so what i did and i did know the risk was drop my last dose to 2roxys and a 2mg xanax. then every 6 hrs or so pop another xanax for about 4 days. now im not saying it worked perfect but it was 10000 times easier than i thot.
    Last edited by HULK1550; 12-27-2010 at 07:22 PM.

  12. #12

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    now i mean thats a lot of shit and it was isnt even doing anything. who needs that shit. that was working and everything. anyways im incredibly eternaly in debt to one person and he knows who he is but basically he told me to cut out everything but the roxys and then cold turkey the bitch lol. now i didnt quite do that. the last dose of roxys i only took 2 and a 2mg xanaxm then every 6 or so hrs i wld take another on for about 5 days and thats it. i was ready to want to die and actually it was pretty fuckin easy so thank you.

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    Quote Originally Posted by HULK1550 View Post
    now i mean thats a lot of shit and it was isnt even doing anything. who needs that shit. that was working and everything. anyways im incredibly eternaly in debt to one person and he knows who he is but basically he told me to cut out everything but the roxys and then cold turkey the bitch lol. now i didnt quite do that. the last dose of roxys i only took 2 and a 2mg xanaxm then every 6 or so hrs i wld take another on for about 5 days and thats it. i was ready to want to die and actually it was pretty fuckin easy so thank you.
    Damn, that's a serious habit you had bro. All those opiates wouldve killed me even when I was at my worst with opiates lol.
    I guess tapering off is crucial.
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

  14. #14
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    how the hell did you afford that habit? I mean, no doc will prescribe you THAT much, unless you doc hopped.
    whats makes it easy for me to stop opiates is the fact that my tolerance SKYROCKETS, and i realize that i have to take ridiculous amounts to achieve the same effect. THats when my internal "off switch" gets activated and i realize "whoa, this aint worth it anymore".
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

  15. #15
    Cyp
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    Quote Originally Posted by ricorico View Post
    how the hell did you afford that habit? I mean, no doc will prescribe you THAT much, unless you doc hopped.
    whats makes it easy for me to stop opiates is the fact that my tolerance SKYROCKETS, and i realize that i have to take ridiculous amounts to achieve the same effect. THats when my internal "off switch" gets activated and i realize "whoa, this aint worth it anymore".
    You'd be surprised what your doctor will prescribe you. I had roxy's then Fentanyl, which takes things to a whole different level. It's amazing how fast your body builds up a tolerance to opiates.

    Hulk, pretty stand up of you to share that with the rest of the community. People need to here this shit, because it happens so fast, and with so many having that "never happen to me" mentality. People like us are much more susceptible to injuries, and likely to face pain killers. Don't get me wrong there is a place for them, it's just something that is over prescribed, and used a quick fix.

  16. #16

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    didnt dr hop. 1 dr started with 60 perc 10s a week then 60 30mg roxys a week then add the 600mcg lolipops then up it to 800mcg lolipops then up to 1600mcg lolipops. now i dont know how many of you have had them but they are no joke. ATALL. There were times when i would suck on 6 of those fuckin things at once! and rico i guess i tapered but not much. once week i stopped the lolipops and went to about 24-30 roxys and then the next morning i took 2 roxys and 1 xanax. >out 6hrs after that 1 xanax 6 hra later another xanax and so on. so i guess if you call going from 30 to 2 a taper then i tapered lol
    Last edited by HULK1550; 12-27-2010 at 07:45 PM.

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    Guess ur right, practically cold. Turkey,...and didn't feel like death?
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

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    Painkillers are the fuckin devil. Period.com

    Cyp and Rico both know about my struggle
    With those fuckers. If it weren't for them
    I wouldn't be were I'm at today. You guys are awsome.

  19. #19

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    Quote Originally Posted by Jrod5150 View Post
    Painkillers are the fuckin devil. Period.com Cyp and Rico both know about my struggle With those fuckers. If it weren't for them I wouldn't be were I'm at today. You guys are awsome.
    damn brother you were on more than me? im not sure ive ever known anyone lol. i usually didnt mix then for example one time i might take 8 16000 lolipops next time i might take 15-18 30mg roxys ect. i just averaged it before. and i did that either 2 or 3 times per day.
    now the reason i went cold turkey was pretty simple. my mnetality. ive always been all or nothing and honestly id build up a tolerance to this shit and know how much of a waste it was but if i tapered by the time i got low enough to go off id change my mind. plus as also w/ my personality i would rather feel like death for a few-5 days than feel shitty for a whole month coming down. so bam. there it was
    now i also think what helped is that while my opiate use was ridiculous i had zero desire for anything else. no coke,no heroin, not even pot or alcohol
    but i cant believe how easy it was.
    Last edited by HULK1550; 12-28-2010 at 01:11 AM.

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    Quote Originally Posted by HULK1550 View Post
    damn brother you were on more than me? im not sure ive ever known anyone lol. i usually didnt mix then for example one time i might take 8 16000 lolipops next time i might take 15-18 30mg roxys ect. i just averaged it before. and i did that either 2 or 3 times per day.
    now the reason i went cold turkey was pretty simple. my mnetality. ive always been all or nothing and honestly id build up a tolerance to this shit and know how much of a waste it was but if i tapered by the time i got low enough to go off id change my mind. plus as also w/ my personality i would rather feel like death for a few-5 days than feel shitty for a whole month coming down. so bam. there it was
    now i also think what helped is that while my opiate use was ridiculous i had zero desire for anything else. no coke,no heroin, not even pot or alcohol
    but i cant believe how easy it was.
    I was off the hook bro. On an average, I took about 30-40 10mg norco's a day. I also took perc's and morphine oh and oxy. Whatever I could get my hands on but
    Drug of choice was norco. The sub's did the trick for me. Slowly tapering is the way to go.

  21. #21
    Cyp
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    I think we can all agree that those pain killers filled a void in our lives. It helped me cope with a lot of garbage that was going on with my life at the time. Sure the high was great, but honestly it gave me this fake sense of feeling good and that I belong with regular society. Something that I struggle with every day. I have developed some great friends here and a positive mind set, which helps me get better. This board has been a source of great friends and support. I will always be open and there for anyone in need of a shoulder to lean on.

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    Quote Originally Posted by Cyp View Post
    I think we can all agree that those pain killers filled a void in our lives. It helped me cope with a lot of garbage that was going on with my life at the time. Sure the high was great, but honestly it gave me this fake sense of feeling good and that I belong with regular society. Something that I struggle with every day. I have developed some great friends here and a positive mind set, which helps me get better. This board has been a source of great friends and support. I will always be open and there for anyone in need of a shoulder to lean on.
    hell yea bro. Ive been there and done that and struggle with opiates for years. I typically refuse to takethem anymore, but With nagging service connected disabilities, i sometimes have no choice but to take take some (unless i dont wanna walk or stand up). Which can be a slippery slope. My doc prescribeds me the 30s when i need em, but I do whatever i can to get by without it. Its been over a year since i beat that terrible addiction, and aside from having to take one or two when i need em, ive been very good and wanna keep it that way. UNfortunately many of my friends are hopelessly hooked on them, and they get em all illegally on the black market paying a premium and living pay check to pay check just trying to line up a buck for their next fix. Its fucking sad.
    Even when I was hooked, 95% of what i took was prescribed to me or my wife...so i never paid that much. I dont understand how people can buy these pills EVERYDAY at these p[rices on the black market.
    Self admitted Yohimburn ES addict
    HIGH DOSE VAR = TREN minus the side effects

    i poop on clen, EQ and nolvadex.

    http://www.ncbi.nlm.nih.gov/pubmed/10492633

    http://www.ncbi.nlm.nih.gov/pubmed/19597031

    http://www.ncbi.nlm.nih.gov/pubmed/18348701

    http://www.ncbi.nlm.nih.gov/pubmed/9364247

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