Hypertrophy vs Hyperplasia

[T-Cake]

I was reading about the difference between muscle hypertrophy and muscle hyperplasia today (as well as that it's debated whether hyperplasia occurs in humans at all).

FIRST... anyone want to give me a simple, easy-to-understand description of hyperplasia? I think I get it but... is it just that muscle fibers would SPLIT wheras in hypertrophy the muscle grows MORE fibers??? :dunno: :help:

SECOND... about that debate part with hyperplasia... is it really that controversial? Does it matter if it happens or not? Pros? Cons of it?

KThanksBye :)

[andrew_plamondon]

Hypertrophy = bigger cells without the formation of new cells
Hyperplasia = formation of new cells

[Lumberjack5.0]

Hypertrophy = bigger cells without the formation of new cells
Hyperplasia = formation of new cells

Right.

T-cake, your proposed def of hypertrophy is actually hyperplasia's def. And as far as I know it's still thought to be a myth. There is some speculation that GH can cause hyperplasia, but I haven't seen a consensus opinion that it's likely.

[T-Cake]

Hypertrophy = bigger cells without the formation of new cells
Hyperplasia = formation of new cells
Awesome, thank you for the clarification. Perfectly simple! :)


Right.

T-cake, your proposed def of hypertrophy is actually hyperplasia's def. And as far as I know it's still thought to be a myth. There is some speculation that GH can cause hyperplasia, but I haven't seen a consensus opinion that it's likely.
So the "myth" thing -- does that apply to law of conservation of matter? I mean, muscle cells generally are not regenerative... or is that fat cells? I know fat cells grow and shrink but none are physicall LOST through weight loss... so I would imagine for weight GAIN and muscle GAIN, it would work the same way... cell growth (therefore only hypertrophy).

And what IF hyperplasia was something GH could cause? What would be the benefit? Strength & volume or just volume?

Curious, that's all. :) I know some of my questions might be tedious and weenie-like, but I really really want to make sure I get this. It's important. ;)

[Lumberjack5.0]

A fresh set of fibers/cells would likely grow faster/easier than the 'old' ones, I would think.

That's really all I 'know' about it.

[andrew_plamondon]

Awesome, thank you for the clarification. Perfectly simple! :)


So the "myth" thing -- does that apply to law of conservation of matter? I mean, muscle cells generally are not regenerative... or is that fat cells? I know fat cells grow and shrink but none are physicall LOST through weight loss... so I would imagine for weight GAIN and muscle GAIN, it would work the same way... cell growth (therefore only hypertrophy).

And what IF hyperplasia was something GH could cause? What would be the benefit? Strength & volume or just volume?

Curious, that's all. :) I know some of my questions might be tedious and weenie-like, but I really really want to make sure I get this. It's important. ;)
Fat cells are just like a bag which can store more or less fat, so this isn't hypertrophy per say. Fat cell hyperplasia can happen in some extreme cases but it's generally rare I think (just like we thought there weren't new neurons, well, there are). Fat cell generally don't go away except for liposuction while neurons... they die !! It's partly why, I think, that lean people have a harder time putting on fat when compared to "leaned out" individuals. We have the storage room all ready for it :ohnoes:

Muscle cells can get bigger through hypertrophy and I don't think hyperplasia is supposed to happen except in some particular cases such as those with a specific version of the now popular myostatin gene.

It's basically what I remember from the whole subject, I might be wrong or maybe new stuff came out but I'm thinking this is pretty much what we know right now.

[get456]

I believe IGF-1 causes Hyperplasia?

proven?

[goldenthree]

Skeletal Muscle Fiber Type (http://home.hia.no/~stephens/hypplas.htm)
Here is a pretty good read about the debate over hyperplasia complete with sources.

[LiftHard410]

simply put,

hypertrophy is growth in physical size of a musle cell by adding nuclei to it, muscle cell's actually have multiple nuclei, or adding more of the proteins responsible for contraction (actin, myosin)

hyperplasia is the development of new cell's via the accelerated/stimulated maturation of satellite cells.
according to everything i have read in med books, igf-1 does cause hyperplasia, but they're vague references

[mike]

a_p hit the nail on the head