Ibuprofen interferes with protein synthesis?

[Mister B.]

Read somewhere that Ibuprofen interferes with protein synthesis. Any truth to this?

I pop the stuff like candies... I'm even contemplating going back on Celebrex.

B

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GETTIN' HARD!!

[This message was edited by Mr. Nobody on 01-13-2003 at 10:25 AM.]

[archive_NubianBeauty]

I read about that in Flex... not sure if it's true though.

[freshr1]

I got an interesting story about this.

My friend was doing 500mg sust/week and gaining very nicely when in his 6th week he decided to up to 1000mg/week. He couldn't handle the injections though, his legs were always swollen and he was in a lot of pain so he started taking a lot of ibuprofin (1-2000mg/day). Lo and behold his growth stopped, just like that. We didn't know about the ibuprofin theory, so we upped his calories a lot (2-4L of ice cream a day, in addition to his other meals) and he started gaining again, but very slowly and nothing like when he was on 500mg.

--
"Your work is both good and original. Unfortunately the part that is good is not original and the part that is original is not good." - Samuel Johnson

[Mister B.]

hmmm... conincidence?

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GETTIN' HARD!!

[freshr1]

<BLOCKQUOTE class="**-ubbcode-quote"><font size="-1">quote:</font><HR>Originally posted by Mister B.:
hmmm... conincidence?

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GETTIN' HARD!!<HR></BLOCKQUOTE>

I don't know. Draw your own conclusions , but I'm staying away from ibuprofin now unless I really really need it. Same with aspirin. Muscular Development had an article about this last summer btw, just as my friend's cycle ended.

--
"Your work is both good and original. Unfortunately the part that is good is not original and the part that is original is not good." - Samuel Johnson

[archive_Mr. Nobody]

http://anabolicfitness.infopop.net/2...3&m=8803095545

is when we discussed this last...I am still not convinced the suppression of protein synthesis is long or sever enough to warrent abstinense. Read the above studies on the cortisol and prolactin suppression...
Also, all those studies are talking about taking it after workouts, what about taking it 1 hour before a workout....would that make a difference?

Disclaimer:
Mr. Nobody is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner.
The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.

[Mister B.]

Yeah, very interesting! I take some first thing in the morning and about an hour before my workout. For now, I'm going to continue to do so... owwwwwieee!!!

Thanks for the link. I did a search but chose ibuprophen... should've tried "pain killer".

B

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GETTIN' HARD!!

[archive_Mr. Nobody]

It still concerns me though that there is so much press out there about the reduced protein synthesis. I really would like to hear from our Phd's such as macro and/or cockdezl.

Disclaimer:
Mr. Nobody is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner.
The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.

[GymRatNYC]

<BLOCKQUOTE class="**-ubbcode-quote"><font size="-1">quote:</font><HR>I did a search but chose ibuprophen... should've tried "pain killer".<HR></BLOCKQUOTE>Try IBUPROFEN. That's the correct spelling.

[Mister B.]

Yes, that helps

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GETTIN' HARD!!

[_GEEZER_]

Stolen from a poster at musclezine.........

Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Trappe, T. A., F. White, C. P. Lambert, D. Cesar, M. Hellerstein, and W. J. Evans. 1Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Center on Aging, Departments of Geriatrics and Physiology and Biophysics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205; and 2Department of Nutritional Sciences, University of California, Berkeley, California 9xxxx
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APStracts 8:0268E, 2001.
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We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high- intensity eccentric resistance exercise. Twenty-four males (25 ± 3 yr, 180 ± 6 cm, 81 ± 6 kg, and 17 ± 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum using the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 ± 19% (P < 0.05) in PLA [0.058 ± 0.012%/h) and was unchanged [P > 0.05) in IBU (35 ± 21%; 0.021 ± 0.014%/h) and ACET (22 ± 23%; 0.010 ± 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle...

	PureCEE PureCEE delivers increased strength, pump and muscular endurance without abdominal bloating or subcutaneous water retention often found with creatine monohydrate. PureCEE uses the finest and purest Creatine Ethyl Ester HCL.

[archive_Mr. Nobody]

Thank you geezer, I actually read that one and a similar one on PGF2A suppression on pubmed before.
Since IMHO PGF2 is worthless for muscle growth anyway, why would suppression of said PG suddenly turn you into Peewee Herman?

I stole that from the elite:
http://boards.elitefitness.com/forum...+muscle+growth
and actually read that opinium before:
Yes both asprin and advil(acetaminophine and ibuprofen) do to some degree inhibit protein synthesis, but one does it approx. 10x more than the other. And the winner(or loser) is asprin, which is good news in a way. Its not an effective antiinflamitory, and in large doses it can cause stomach bleeding, ulcers, etc. Its only good for pain relief. Advil will also slow down protein sythesis and thus muscle recovery, but to a much lesser degree. At a 1000 mg. its also an effective anti-inflammitory, and it doesn't cause gastro-intestinal bleeding. The anti-inflammitory part is the important one for advil, since once you have muscle/tendon/soft tissue swelling there is going to be very little healing happening until the swelling goes down. That's why anti-inflammitories and ice are the athletes friend. This means that although advil may slightly slow down muscle growth, it can more importantly keep slight strains, pains etc. from flairing up into total workout stopping ones. How many of you guys have been training long term using advil and ice when needed before reading this, and made gains? Like all drugs, there is a proper way to use them, and its easy to abuse them. Asprin is only a pain killer and thus worthless-if you can't deal with the pain of intense training then get out. Injury and strain pain is a different story. you deal with injurys as fast as possible with advil 800-1000 mg once to twice a day and ice 2-3 times a day for 10-20 min. so you can recover and get you ass back in the gym training hard. So basically if your in the habit of just popping asprin or advil cuz it can't hurt-stop. However if you have tendinitis, bursitis, whatever and need advil to keep down swelling so you can train hard, then go for it.

Again I will not toss my pretreatment of 400mg ibu, since it has helped me greatly manage my inflamation in elbow, shoulder and knee; I will continue with this parctice until I have been convinced otherwise by our proffessors

Oh and my bench has been going up steadily....not bad for a "post exercise protein synthesis killer"

Disclaimer:
Mr. Nobody is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner.
The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.

	ASS Nelson Montana

[_GEEZER_]

Hey Mr. Nobody, whatever works for ya. Even if someone says it's stupid;

If it's stupid AND IT WORKS, it's not stupid!

[swale]

It seems that the inflammatory response secondary to hard training somehow is necessary for muscle growth. I was shown, years ago, that taking a lot of aspirin reduced gains. I'd already figured that out on my own.

ANY ADVICE I MAY GIVE IS JUST FOR SHITS AND GIGGLES, AND DOES NOT SUBSTITUTE FOR A PROPER EVALUATION BY A PHYSICIAN.

[archive_Killer]

Just to throw it out there, if you are looking for all day anti inflammation relief, try alieve. It lasts 12 hours. Two at a time is the same as the prescription dose of naproism (sp?).