Clomiphene study

archive_MR. BMJ · 11-02-2002, 04:32 PM

Maybe this will be of interest or not, but i'll post it anyway.

BMJ

Andrologia
Volume 34 Issue 5 Page 308 - October 2002

Basal serum testosterone as an indicator of response to clomiphene treatment in human epididymis, seminal vesicles and prostate
G. F. Gonzales
Summary.
The present study was designed to determine the response of human epididymis, seminal vesicles and prostate function after a 5-day course of clomiphene citrate in men attending an infertility service. In 45 men, the secretions of the epididymis, seminal vesicles and prostate were assessed by measurements of seminal -glucosidase, fructose and acid phosphatase, respectively. Subjects were classified as normal or abnormal: abnormal men were defined as those who either had history of a sexually transmitted disease (STD), leukocytospermia, hypoandrogenism, or a low response of Leydig cells to clomiphene stimulation; and normal subjects were those who did not have these conditions.

Mean serum testosterone luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were significantly increased after the short course with clomiphene citrate. After clomiphene citrate stimulation, the men in the normal group showed significantly increased marker levels of the seminal vesicles (P< 0.02) and prostate [P< 0.05), but not of the epididymis [P : NS). Men classified as abnormal showed no response according to the markers of the seminal vesicles and epididymis. Men with history of STD and abnormal basal values of acid phosphatase did not respond to the treatment. Men with history of STD but normal basal values of seminal acid phosphatase increased significantly in their levels of seminal acid phosphatase after clomiphene stimulation [P< 0.02).

Multivariate analysis showed that the basal serum testosterone level was the only variable in predicting the probability of response to the clomiphene in terms of true-corrected seminal fructose, seminal acid phosphatase and seminal -glucosidase levels. In fact, a high response of the seminal vesicles was observed in men with the highest basal serum testosterone levels (0.45 ± 0.17; coefficient of regression ± standard error; P< 0.018). However, a high response in terms of seminal acid phosphatase [P< 0.004) or -glucosidase [P< 0.037) was observed in men with low basal serum testosterone levels.

In conclusion, in the normal men, true-corrected fructose and acid phosphatase but not -glucosidase in semen increased after duplicate androgen stimulation. An absence of response was observed in cases with history of STD/leukocytospermia or hypoandrogenism.

archive_Ulter · 11-02-2002, 04:40 PM

I am in the "good" group. It would work for me.

archive_MR. BMJ · 11-02-2002, 04:40 PM

Might as well throw this in as well. It's nothing we don't already know, but it is nice to see it publicated in research.

Archives of Andrology
Publisher: Taylor & Francis Health Sciences, part of the Taylor & Francis Group
Issue: Volume 48, Number 6/November 01, 2002
Pages: 433 - 442
URL: Linking Options

Patient Satisfaction with Testosterone Supplementation for the Treatment of Erectile Dysfunction

M. Monga A1, M. Kostelec A2, M. Kamarei A3

A1 Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota, USA (USA)
A2 Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota, USA (USA)
A3 Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota, USA (USA)

Abstract:

The long-term efficacy of testosterone supplementation for erectile dysfunction was evaluated using standardized questionnaires and differences between testosterone delivery systems analyzed. Forty-four patients receiving parenteral depo-testosterone, Testoderm scrotal patches, or Testoderm-TTS nonscrotal patches were evaluated with the Erectile Dysfunction Inventory of Treatment Satisfaction and International Index of Erectile Function questionnaires. Global questions regarding libido, energy, and improved erections demonstrated a significantly better response with depo-testosterone and Testoderm-TTS nonscrotal patches as compared to Testoderm scrotal patches. Testoderm-TTS nonscrotal patches and depo-testosterone resulted in significantly higher overall treatment satisfaction (p <.001), confidence in ability to engage in sexual activity [p <.001), and total Erectile Dysfunction Inventory of Treatment Satisfaction and International Index of Erectile Function scores [p <.001). Testoderm-TTS nonscrotal patches were significantly better than depo-testosterone with regard to satisfaction with sexual intercourse [International Index of Erectile Function question 5, p <.05). Testosterone replacement improved the quality of erections and level of libido in patients with erectile dysfunction. Treatment delivery systems appear to impact the success of therapy.

BMJ

11-02-2002, 04:32 PM	#1 (permalink)
archive_MR. BMJ Senior Member Join Date: Nov 2000 Posts: 1,869 Rep Power: 7960	Clomiphene study Maybe this will be of interest or not, but i'll post it anyway. BMJ Andrologia Volume 34 Issue 5 Page 308 - October 2002 Basal serum testosterone as an indicator of response to clomiphene treatment in human epididymis, seminal vesicles and prostate G. F. Gonzales Summary. The present study was designed to determine the response of human epididymis, seminal vesicles and prostate function after a 5-day course of clomiphene citrate in men attending an infertility service. In 45 men, the secretions of the epididymis, seminal vesicles and prostate were assessed by measurements of seminal -glucosidase, fructose and acid phosphatase, respectively. Subjects were classified as normal or abnormal: abnormal men were defined as those who either had history of a sexually transmitted disease (STD), leukocytospermia, hypoandrogenism, or a low response of Leydig cells to clomiphene stimulation; and normal subjects were those who did not have these conditions. Mean serum testosterone luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were significantly increased after the short course with clomiphene citrate. After clomiphene citrate stimulation, the men in the normal group showed significantly increased marker levels of the seminal vesicles (P< 0.02) and prostate [P< 0.05), but not of the epididymis [P : NS). Men classified as abnormal showed no response according to the markers of the seminal vesicles and epididymis. Men with history of STD and abnormal basal values of acid phosphatase did not respond to the treatment. Men with history of STD but normal basal values of seminal acid phosphatase increased significantly in their levels of seminal acid phosphatase after clomiphene stimulation [P< 0.02). Multivariate analysis showed that the basal serum testosterone level was the only variable in predicting the probability of response to the clomiphene in terms of true-corrected seminal fructose, seminal acid phosphatase and seminal -glucosidase levels. In fact, a high response of the seminal vesicles was observed in men with the highest basal serum testosterone levels (0.45 ± 0.17; coefficient of regression ± standard error; P< 0.018). However, a high response in terms of seminal acid phosphatase [P< 0.004) or -glucosidase [P< 0.037) was observed in men with low basal serum testosterone levels. In conclusion, in the normal men, true-corrected fructose and acid phosphatase but not -glucosidase in semen increased after duplicate androgen stimulation. An absence of response was observed in cases with history of STD/leukocytospermia or hypoandrogenism.

11-02-2002, 04:40 PM	#2 (permalink)
archive_Ulter Senior Member Join Date: Nov 2000 Posts: 15,388 Rep Power: 21906	I am in the "good" group. It would work for me. __________________

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11-02-2002, 04:40 PM	#3 (permalink)
archive_MR. BMJ Senior Member Join Date: Nov 2000 Posts: 1,869 Rep Power: 7960	Might as well throw this in as well. It's nothing we don't already know, but it is nice to see it publicated in research. Archives of Andrology Publisher: Taylor & Francis Health Sciences, part of the Taylor & Francis Group Issue: Volume 48, Number 6/November 01, 2002 Pages: 433 - 442 URL: Linking Options Patient Satisfaction with Testosterone Supplementation for the Treatment of Erectile Dysfunction M. Monga A1, M. Kostelec A2, M. Kamarei A3 A1 Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota, USA (USA) A2 Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota, USA (USA) A3 Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota, USA (USA) Abstract: The long-term efficacy of testosterone supplementation for erectile dysfunction was evaluated using standardized questionnaires and differences between testosterone delivery systems analyzed. Forty-four patients receiving parenteral depo-testosterone, Testoderm scrotal patches, or Testoderm-TTS nonscrotal patches were evaluated with the Erectile Dysfunction Inventory of Treatment Satisfaction and International Index of Erectile Function questionnaires. Global questions regarding libido, energy, and improved erections demonstrated a significantly better response with depo-testosterone and Testoderm-TTS nonscrotal patches as compared to Testoderm scrotal patches. Testoderm-TTS nonscrotal patches and depo-testosterone resulted in significantly higher overall treatment satisfaction (p <.001), confidence in ability to engage in sexual activity [p <.001), and total Erectile Dysfunction Inventory of Treatment Satisfaction and International Index of Erectile Function scores [p <.001). Testoderm-TTS nonscrotal patches were significantly better than depo-testosterone with regard to satisfaction with sexual intercourse [International Index of Erectile Function question 5, p <.05). Testosterone replacement improved the quality of erections and level of libido in patients with erectile dysfunction. Treatment delivery systems appear to impact the success of therapy. BMJ