How can I lower Estrone?

Carth · 03-01-2008, 10:47 PM

Adex and Aromasin lower my Estradiol. But what about Estrone? What will do it?

Blut Wump · 03-01-2008, 11:06 PM

May I point you to this thread? Arimedex vs AIFM

Macro has some pertinent posts there.

solidspine · 03-01-2008, 11:33 PM

I would suspect AIFM 2-pumps a day

You really are getting technical, are you trying to get your BF% below 6 or something?

Carth · 03-02-2008, 09:00 AM

Quote:

Originally Posted by solidspine

I would suspect AIFM 2-pumps a day

You really are getting technical, are you trying to get your BF% below 6 or something?

Believe me 100%. And I swear on my LIFE! That AIFM does NOT lower Estrone. I know this because of bloodwork. Again.....IT DOES NOT AND WILL NOT LOWER ESTRONE!!!

Blut Wump · 03-02-2008, 09:24 AM

If all else fails, letro should do a number on all your oestrogen.

Carth · 03-02-2008, 09:41 AM

Quote:

Originally Posted by Blut Wump

If all else fails, letro should do a number on all your oestrogen.

Letro really would do that? Attack ALL estrogens? I have tons of the stuff here. Havent' used it in a looooong time. What's the normal dosage? 1.25mgs ED?

buzz · 03-02-2008, 09:46 AM

letro is some very strong stuff. It will suppress everything (e related).How much test are you on? 1.25 ED might very well be too suppressive.
Perhaps E3D would be a better start.

Blut Wump · 03-02-2008, 09:56 AM

Yes, if I recall correctly, letro hits all oestrogen conversion pathways, resulting in very high levels of oestrogen suppression. You'll need to experiment to find your own needs. 2.5mg ED is used as an emergency dose when gyno strikes. On-cycle dosing can vary between 1.25mg ED down to 0.5mg EoD or less.

One minor hassle with letro is that it has a longish half-life and so it can take upto three days to feel a difference from a change in dose. That makes it a little harder to find your optimal dose.

solidspine · 03-02-2008, 10:11 AM

Quote:

Believe me 100%. And I swear on my LIFE! That AIFM does NOT lower Estrone. I know this because of bloodwork. Again.....IT DOES NOT AND WILL NOT LOWER ESTRONE!!!

I beleive you,

Ulter · 03-02-2008, 02:26 PM

Why do you want to lower estrone? It has almost no impact on the rest of the endocrine system. It's very weak and even if you ELIMINATED IT, you'd never feel the difference.

MR. BMJ · 03-02-2008, 03:27 PM

Macrophage69alpha:

Quote:

when it comes to this comparison its more about type of estrogen suppression as opposed to "strength". Arimidex is a VERY potent sulfatase inhibitor, which inhibits estrone. It is a moderately strong aromatase inhibitor (weak as compared to aromasin, AIFM or letrozole). This is fine for women with breast cancer who produce percentage wise very high levels of estrone (the weak estrogen), which can be converted to estradiol (the strong estrogen) via aromatase.

For men this is generally not very good, especially for men on TRT since sulfatase inhibitors have very little effect on exogenous testosterone. Actually its generally not a good thing since it nearly completely eliminates estrone, while still allowing estradiol. If you have a choice as a man, you want estrone (weak estrogen) with near total elimination of estradiol (strong). AIFM and aromasin do inhibit sulfatase, though to a lesser extent than the competitive inhibitors (dex and letro). They are both potent aromatase inhibitors and highly suppress estradiol. Since exogenous test converts to estradiol via aromatase, AIFM and aromasin are much better suited.
AIFM
AI For Men uses ATD, a natural steroidal aromatase inhibitor comparable to Aromasin in results.

MR. BMJ · 03-02-2008, 03:33 PM

If you cut down estradiol, you at least want some form of weak E for sex drive, this would be a good time to have estrone within normal limits.

So AIFM/Aromasin--good for estradiol.

Letro---cuts down all 3 E's.

Arimidex---cuts down estrone.

If you use Letro, AIFM or Aromasin for Estradiol, then do not try to totally lower estrone. I believe you are taking Rx Aromasin, so keep that going, and it will cut down Estradiol. You can add Arimidex to the equation for estrone, but that might drive total E down too much.

I'd take Letro by itself first before stacking 2 AI's together. But even then, you will need some trial and error for dosing correctly

BMJ

BIG SMT · 03-02-2008, 06:21 PM

That would explain why Letro has an ED effect.

HULK1550 · 03-03-2008, 07:52 AM

carth is it possible also that your body does not respond to certain substances as most would? i dont think thats a stretch given the problems you have had.

not everyone responds identically to the same substances. i think we all know that.

Carth · 03-03-2008, 08:03 AM

Quote:

Originally Posted by HULK1550

carth is it possible also that your body does not respond to certain substances as most would? i dont think thats a stretch given the problems you have had.

not everyone responds identically to the same substances. i think we all know that.

Without a doubt. That is possible.

Thoxi · 03-03-2008, 09:36 AM

Carth, you say you have bloodwork to show AIFM didn't touch your estrone... Do you also have bloodwork that shows to what a degree it lowered oestrogen and/or thereby elevated test/free test?

I know it does, but to what degree I mean.

I would greatly appreciate having some reference values to my soon-to-be-own.

03-01-2008, 10:47 PM	#1 (permalink)
Carth Gold Member Join Date: Feb 2007 Posts: 311 Rep Power: 2440	How can I lower Estrone? Adex and Aromasin lower my Estradiol. But what about Estrone? What will do it?

03-02-2008, 09:46 AM	#7 (permalink)
buzz Gold Member Join Date: Feb 2001 Posts: 192 Rep Power: 7270	letro is some very strong stuff. It will suppress everything (e related).How much test are you on? 1.25 ED might very well be too suppressive. Perhaps E3D would be a better start. Last edited by buzz; 03-02-2008 at 09:54 AM..

03-02-2008, 02:26 PM	#10 (permalink)
Ulter Chairman of the board Join Date: Feb 2000 Location: Orlando Posts: 28,326 Rep Power: 457702	Why do you want to lower estrone? It has almost no impact on the rest of the endocrine system. It's very weak and even if you ELIMINATED IT, you'd never feel the difference. __________________ > . . When you register at www.theafstore.com make sure you register as an AF Board Member to get the discounted pricing.

03-01-2008, 11:06 PM	#2 (permalink)
Blut Wump The Venerable Wump Join Date: Feb 2007 Location: UK Posts: 7,883 Rep Power: 613806	May I point you to this thread? Arimedex vs AIFM Macro has some pertinent posts there.

03-02-2008, 09:24 AM	#5 (permalink)
Blut Wump The Venerable Wump Join Date: Feb 2007 Location: UK Posts: 7,883 Rep Power: 613806	If all else fails, letro should do a number on all your oestrogen.

03-02-2008, 09:56 AM	#8 (permalink)
Blut Wump The Venerable Wump Join Date: Feb 2007 Location: UK Posts: 7,883 Rep Power: 613806	Yes, if I recall correctly, letro hits all oestrogen conversion pathways, resulting in very high levels of oestrogen suppression. You'll need to experiment to find your own needs. 2.5mg ED is used as an emergency dose when gyno strikes. On-cycle dosing can vary between 1.25mg ED down to 0.5mg EoD or less. One minor hassle with letro is that it has a longish half-life and so it can take upto three days to feel a difference from a change in dose. That makes it a little harder to find your optimal dose.

03-02-2008, 06:21 PM	#13 (permalink)
BIG SMT Gold Member Join Date: Feb 2006 Posts: 721 Rep Power: 23150	That would explain why Letro has an ED effect.

03-03-2008, 07:52 AM	#14 (permalink)
HULK1550 Super Moderator Join Date: Feb 2000 Posts: 3,378 Rep Power: 58372	carth is it possible also that your body does not respond to certain substances as most would? i dont think thats a stretch given the problems you have had. not everyone responds identically to the same substances. i think we all know that.