If it were me I would apply a hot compress to the area for 10 min. or so, then dig my thumb in, find the knot and and start pushing it out. It'll take your breath away in the short run, but will help overall. Ice it afterward, and often, for a few days.
After every shot if you'll apply firm pressure to the shot site for a minute or so, it'll help dissapate the medicine, and lessen the probability if a repeat occurence.
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